2fji

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Image:2fji.gif

2fji, resolution 2.40Å

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Crystal structure of the C-terminal domain of the exocyst subunit Sec6p

Overview

The exocyst is a conserved protein complex essential for trafficking secretory vesicles to the plasma membrane. The structure of the C-terminal domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the C-terminal domains of Exo84p and Sec15, despite <10% sequence identity. The helical bundles appear to be evolutionarily related molecular scaffolds that have diverged to create functionally distinct exocyst proteins.

About this Structure

2FJI is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles., Sivaram MV, Furgason ML, Brewer DN, Munson M, Nat Struct Mol Biol. 2006 Jun;13(6):555-6. Epub 2006 May 14. PMID:16699513

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