3ozu
From Proteopedia
Contents |
The Crystal Structure of flavohemoglobin from R. eutrophus in complex with miconazole
Template:ABSTRACT PUBMED 21210640
Function
[HMP_RALEH] Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.[HAMAP-Rule:MF_01252] In the presence of oxygen and NADH, FHP has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2), both in vitro and in vivo, and it has been suggested that FHP might act as an amplifier of superoxide stress. Under anaerobic conditions, FHP also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.[HAMAP-Rule:MF_01252]
About this Structure
3ozu is a 1 chain structure with sequence from Cupriavidus necator. Full crystallographic information is available from OCA.
Reference
- El Hammi E, Warkentin E, Demmer U, Limam F, Marzouki NM, Ermler U, Baciou L. Structure of Ralstonia eutropha Flavohemoglobin in Complex with Three Antibiotic Azole Compounds. Biochemistry. 2011 Feb 22;50(7):1255-1264. Epub 2011 Jan 20. PMID:21210640 doi:10.1021/bi101650q
