3pfg

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Template:STRUCTURE 3pfg

Contents 1 X-Ray crystal structure the N,N-dimethyltransferase TylM1 from Streptomyces fradiae in complex with SAM and dTDP-phenol 2 Function 3 About this Structure 4 Reference

X-Ray crystal structure the N,N-dimethyltransferase TylM1 from Streptomyces fradiae in complex with SAM and dTDP-phenol

Template:ABSTRACT PUBMED 21142177

Function

[P95748_STRFR] S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin. Involved in the last step in mycaminose biosynthesis by mediating dimethylation of the hexose C-3' amino group.^{[1] [2] [3]}

About this Structure

3pfg is a 1 chain structure with sequence from Streptomyces fradiae. Full crystallographic information is available from OCA.

Reference

• Carney AE, Holden HM. Molecular Architecture of TylM1 from Streptomyces fradiae: an N,N-Dimethyltransferase Involved in the Production of dTDP-D-Mycaminose. Biochemistry. 2010 Dec 13. PMID:21142177 doi:10.1021/bi101733y

1. ↑ Gandecha AR, Large SL, Cundliffe E. Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome. Gene. 1997 Jan 15;184(2):197-203. PMID:9031628
2. ↑ Chen H, Yamase H, Murakami K, Chang CW, Zhao L, Zhao Z, Liu HW. Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine. Biochemistry. 2002 Jul 23;41(29):9165-83. PMID:12119032
3. ↑ Carney AE, Holden HM. Molecular Architecture of TylM1 from Streptomyces fradiae: an N,N-Dimethyltransferase Involved in the Production of dTDP-D-Mycaminose. Biochemistry. 2010 Dec 13. PMID:21142177 doi:10.1021/bi101733y