1sln
From Proteopedia
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THE N-CARBOXY-ALKYL INHIBITOR L-702,842
Overview
The proteolytic enzyme stromelysin-1 is a member of the family of matrix, metalloproteinases and is believed to play a role in pathological, conditions such as arthritis and tumor invasion. Stromelysin-1 is, synthesized as a pro-enzyme that is activated by removal of an N-terminal, prodomain. The active enzyme contains a catalytic domain and a C-terminal, hemopexin domain believed to participate in macromolecular substrate, recognition. We have determined the three-dimensional structures of both a, C-truncated form of the proenzyme and an inhibited complex of the, catalytic domain by X-ray diffraction analysis. The catalytic core is very, similar in the two forms and is similar to the homologous domain in, fibroblast and neutrophil collagenases, as well as to the stromelysin, structure ... [(full description)]
About this Structure
1SLN is a [Single protein] structure of sequence from [Homo sapiens] with ZN, CA and INH as [ligands]. Active as [Stromelysin 1], with EC number [3.4.24.17]. Structure known Active Sites: CA1, CA2, CA3, INH, ZN1 and ZN2. Full crystallographic information is available from [OCA].
Reference
Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme., Becker JW, Marcy AI, Rokosz LL, Axel MG, Burbaum JJ, Fitzgerald PM, Cameron PM, Esser CK, Hagmann WK, Hermes JD, et al., Protein Sci. 1995 Oct;4(10):1966-76. PMID:8535233
Page seeded by OCA on Tue Oct 30 16:04:21 2007
Categories: Homo sapiens | Single protein | Stromelysin 1 | Becker, J.W. | CA | INH | ZN | Collagen degradation | Fibroblast | Hydrolase | Metalloprotease
