This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1ae7
From Proteopedia
|
NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2
Overview
The three-dimensional structure of notexin has been solved by molecular, replacement methods. The structure has been refined at 2.0 A resolution to, a crystallographic R-value of 16.5% with good stereo-chemistry. The core, of the protein is very similar to other phospholipase A2s (PLA2 s) but, several parts of the molecule are distinctly different. The most, significant differences from PLA2 s from bovine pancreas and rattlesnake, occur in the stretches 56-80 and 85-89. Residue 69, which has been shown, to be important for phospholipase binding, has a different conformation, and different interactions than in other known PLA2s. The C alpha, positions for residues 86-88 differ by about 6 A from both the bovine and, the rattlesnake enzyme. The crystals contain no Ca2+ ions. Instead, a, ... [(full description)]
About this Structure
1AE7 is a [Single protein] structure of sequence from [[1]] with SO4 as [ligand]. Active as [[2]], with EC number [3.1.1.4]. Full crystallographic information is available from [OCA].
Reference
The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution., Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H, FEBS Lett. 1992 Apr 20;301(2):159-64. PMID:1568473
Page seeded by OCA on Mon Oct 29 16:28:34 2007
