This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1svp
From Proteopedia
|
SINDBIS VIRUS CAPSID PROTEIN
Overview
BACKGROUND: Many enveloped viruses exit cells by budding from the plasma, membrane. The driving force for budding is the interaction of an inner, protein nucleocapsid core with transmembrane glycoprotein spikes. The, molecular details of this process are ill defined. Alphaviruses, such as, Sindbis virus (SINV) and Semliki Forest virus (SFV), represent some of the, simplest enveloped viruses and have been well characterized by structural, genetic and biochemical techniques. Although a high-resolution structure, of an alphavirus has not yet been attained, cryo-electron microscopy, (cryo-EM) has been used to show the multilayer organization at 25 A, resolution. In addition, atomic resolution studies are available of the, C-terminal domain of the nucleocapsid protein and this has been ... [(full description)]
About this Structure
1SVP is a [Single protein] structure of sequence from [Sindbis virus]. Structure known Active Site: TRI. Full crystallographic information is available from [OCA].
Reference
Identification of a protein binding site on the surface of the alphavirus nucleocapsid and its implication in virus assembly., Lee S, Owen KE, Choi HK, Lee H, Lu G, Wengler G, Brown DT, Rossmann MG, Kuhn RJ, Structure. 1996 May 15;4(5):531-41. PMID:8736552
Page seeded by OCA on Tue Oct 30 16:04:47 2007
