2fw3

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Image:2fw3.gif

2fw3, resolution 2.50Å

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Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326

Overview

Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.

About this Structure

2FW3 is a Single protein structure of sequence from Rattus norvegicus with as ligand. Active as Carnitine O-palmitoyltransferase, with EC number 2.3.1.21 Full crystallographic information is available from OCA.

Reference

A monotopic membrane protein goes solo., Mattevi A, Structure. 2006 Apr;14(4):628-9. PMID:16615901

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