User:Samuel Carlson/Sandbox 1
From Proteopedia
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Bromodomain Structure
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Role in the Nucleolar Remodeling Complex (NoRC)
BAZ2A interacts with sucrose-nonfermenting protein 2 homolog (SNF2H) to form the NoRC, which recruits histone methyltransferases, histone deacetylases, and DNA methyltransferases. The NoRC silences transcription by modifying DNA compaction, as well as by interfering with ribosomal RNA (rRNA) transcription. (CITE) BAZ2a is thought to direct transcriptional repression by binding to histones labeled with posttranslational modifications (PTMs) such as acetylation on lysine residues.
Role in Chromatin Remodeling
As a critical member of the NoRC, BAZ2a in conjunction with SNF2H is responsible for modifying the compaction of chromatin, through The NoRC is also responsible for ribosomal DNA (rDNA) transcription silencing, by recruiting histone deacetylase (HDAC) and DNA methyltransferase (DNMT) to the rDNA promoter, effectively creating a region with the characteristics of heterochromatin and silencing rDNA transcription. [1]
