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4iw5

From Proteopedia

Revision as of 06:40, 8 May 2013 by OCA (Talk | contribs)
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Template:STRUCTURE 4iw5

Contents

Thymidylate synthase ternary complex with dUMP and CB3717

Template:ABSTRACT PUBMED 23611499

Function

[TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.

About this Structure

4iw5 is a 2 chain structure with sequence from Escherichia coli k-12. This structure supersedes the now removed PDB entry 2g8o. Full crystallographic information is available from OCA.

Reference

  • Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28. PMID:16768437 doi:10.1021/bi060152s

Proteopedia Page Contributors and Editors (what is this?)

OCA, Jaime Prilusky

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