3pnl

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Template:STRUCTURE 3pnl

Contents 1 Crystal Structure of E.coli Dha kinase DhaK-DhaL complex 2 Function 3 About this Structure 4 Reference

Crystal Structure of E.coli Dha kinase DhaK-DhaL complex

Template:ABSTRACT PUBMED 21209328

Function

[DHAK_ECOLI] Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of DhaR by binding to its sensor domain, in the absence of dihydroxyacetone. [DHAL_ECOLI] ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaL-ADP receives a phosphoryl group from DhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sensor domain of DhaR. DhaL-ATP is inactive.

About this Structure

3pnl is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

• Shi R, McDonald L, Cui Q, Matte A, Cygler M, Ekiel I. Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase. Proc Natl Acad Sci U S A. 2011 Jan 5. PMID:21209328 doi:10.1073/pnas.1012596108