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3pr2
From Proteopedia
Contents |
Tryptophan synthase indoline quinonoid structure with F9 inhibitor in alpha site
Template:ABSTRACT PUBMED 21142052
Function
[TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [TRPB_SALTY] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
About this Structure
3pr2 is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhimurium. Full crystallographic information is available from OCA.
See Also
Reference
- Lai J, Niks D, Wang Y, Domratcheva T, Barends TR, Schwarz F, Olsen RA, Elliott DW, Fatmi MQ, Chang CE, Schlichting I, Dunn MF, Mueller LJ. X-ray and NMR crystallography in an enzyme active site: the indoline quinonoid intermediate in tryptophan synthase. J Am Chem Soc. 2011 Jan 12;133(1):4-7. Epub 2010 Dec 10. PMID:21142052 doi:10.1021/ja106555c
Categories: Salmonella enterica subsp. enterica serovar typhimurium | Tryptophan synthase | Barends, T R.M. | Chang, C A. | Domratcheva, T. | Dunn, M F. | Elliott, D W. | Fatmi, M Q. | Lai, J. | Mueller, L J. | Niks, D. | Olsen, R A. | Schlichting, I. | Schwarz, F. | Wang, Y. | Alpha-beta barrel | Lyase | Tim-barrel | Tryptophan synthesis
