3q5f

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Template:STRUCTURE 3q5f

Contents 1 Crystal structure of the Salmonella transcriptional regulator SlyA in complex with DNA 2 Function 3 About this Structure 4 Reference

Crystal structure of the Salmonella transcriptional regulator SlyA in complex with DNA

Template:ABSTRACT PUBMED 21550983

Function

[SLYA_SALTY] Transcription regulator that can specifically activate or repress expression of target genes. Required for virulence and survival in the macrophage environment. Probably activates expression of ispA, xseB genes, and of omp operon.^{[1] [2]}

About this Structure

3q5f is a 4 chain structure with sequence from Salmonella enterica. Full crystallographic information is available from OCA.

Reference

• Dolan KT, Duguid EM, He C. Crystal structures of SlyA, a master virulence regulator of Salmonella, in free and DNA-bound states. J Biol Chem. 2011 May 5. PMID:21550983 doi:10.1074/jbc.M111.245258

1. ↑ Ludwig A, Tengel C, Bauer S, Bubert A, Benz R, Mollenkopf HJ, Goebel W. SlyA, a regulatory protein from Salmonella typhimurium, induces a haemolytic and pore-forming protein in Escherichia coli. Mol Gen Genet. 1995 Dec 15;249(5):474-86. PMID:8544813
2. ↑ Buchmeier N, Bossie S, Chen CY, Fang FC, Guiney DG, Libby SJ. SlyA, a transcriptional regulator of Salmonella typhimurium, is required for resistance to oxidative stress and is expressed in the intracellular environment of macrophages. Infect Immun. 1997 Sep;65(9):3725-30. PMID:9284144