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3q9e

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Template:STRUCTURE 3q9e

Contents

Crystal structure of H159A APAH complexed with acetylspermine

Template:ABSTRACT PUBMED 21268586

Function

[APHA_MYCRA] Acts on many types of acetylpolyamines. Has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine. Acts on L-Lys-(epsilon-acetyl)-coumarin, but has very low activity towards acetylated peptides.

About this Structure

3q9e is a 12 chain structure with sequence from Mycoplana ramosa. Full crystallographic information is available from OCA.

Reference

  • Lombardi PM, Angell HD, Whittington DA, Flynn EF, Rajashankar KR, Christianson DW. Structure of Prokaryotic Polyamine Deacetylase Reveals Evolutionary Functional Relationships with Eukaryotic Histone Deacetylases . Biochemistry. 2011 Jan 26. PMID:21268586 doi:10.1021/bi101859k

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