3qnt

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Template:STRUCTURE 3qnt

Contents

NPC1L1 (NTD) Structure

Template:ABSTRACT PUBMED 21525977

Function

[NPCL1_HUMAN] Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.[1] [2]

About this Structure

3qnt is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kwon HJ, Palnitkar M, Deisenhofer J. The Structure of the NPC1L1 N-Terminal Domain in a Closed Conformation. PLoS One. 2011 Apr 15;6(4):e18722. PMID:21525977 doi:10.1371/journal.pone.0018722
  1. ↑ Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, Crona JH, Davis HR Jr, Dean DC, Detmers PA, Graziano MP, Hughes M, Macintyre DE, Ogawa A, O'neill KA, Iyer SP, Shevell DE, Smith MM, Tang YS, Makarewicz AM, Ujjainwalla F, Altmann SW, Chapman KT, Thornberry NA. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132-7. Epub 2005 May 31. PMID:15928087 doi:10.1073/pnas.0500269102
  2. ↑ Yamanashi Y, Takada T, Shoda J, Suzuki H. Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein. Hepatology. 2012 Mar;55(3):953-64. doi: 10.1002/hep.24772. Epub 2012 Jan 30. PMID:22095670 doi:10.1002/hep.24772

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