2xhl

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Template:STRUCTURE 2xhl

Contents

STRUCTURE OF A FUNCTIONAL DERIVATIVE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE B

Template:ABSTRACT PUBMED 21078393

Function

[BXB_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.

About this Structure

2xhl is a 2 chain structure with sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

Reference

  • Masuyer G, Beard M, Cadd VA, Chaddock JA, Acharya KR. Structure and activity of a functional derivative of Clostridium botulinum neurotoxin B. J Struct Biol. 2010 Nov 13. PMID:21078393 doi:10.1016/j.jsb.2010.11.010

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