3qf7

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Template:STRUCTURE 3qf7

Contents 1 The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair 2 Function 3 About this Structure 4 See Also 5 Reference

The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair

Template:ABSTRACT PUBMED 21458667

Function

[RAD50_THEMA] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity).

About this Structure

3qf7 is a 4 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

See Also

• ATPase

Reference

• Lammens K, Bemeleit DJ, Mockel C, Clausing E, Schele A, Hartung S, Schiller CB, Lucas M, Angermuller C, Soding J, Strasser K, Hopfner KP. The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair. Cell. 2011 Apr 1;145(1):54-66. PMID:21458667 doi:10.1016/j.cell.2011.02.038