4fqg

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Template:STRUCTURE 4fqg

Contents 1 Crystal structure of the TCERG1 FF4-6 tandem repeat domain 2 Function 3 About this Structure 4 Reference

Crystal structure of the TCERG1 FF4-6 tandem repeat domain

Template:ABSTRACT PUBMED 23436654

Function

[TCRG1_HUMAN] Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.^{[1] [2]}

About this Structure

4fqg is a 2 chain structure with sequence from [1] and Homo sapiens. Full crystallographic information is available from OCA.

Reference

1. ↑ Sune C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA. CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription. Mol Cell Biol. 1997 Oct;17(10):6029-39. PMID:9315662
2. ↑ Goldstrohm AC, Albrecht TR, Sune C, Bedford MT, Garcia-Blanco MA. The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. Mol Cell Biol. 2001 Nov;21(22):7617-28. PMID:11604498 doi:10.1128/MCB.21.22.7617-7628.2001