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Template:STRUCTURE 4jgq

Contents 1 The crystal structure of sporulation kinase D mutant sensor domain, r131a, from Bacillus subtilis subsp in co-crystallization with pyruvate 2 Function 3 About this Structure 4 Reference

The crystal structure of sporulation kinase D mutant sensor domain, r131a, from Bacillus subtilis subsp in co-crystallization with pyruvate

Template:ABSTRACT PUBMED 23436677

Function

[KIND_BACSU] Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions.^{[1] [2] [3]}

About this Structure

4jgq is a 2 chain structure with sequence from Bacillus subtilis subsp. subtilis str. 168. This structure supersedes the now removed PDB entry 4dak. Full crystallographic information is available from OCA.

Reference

1. ↑ Jiang M, Shao W, Perego M, Hoch JA. Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis. Mol Microbiol. 2000 Nov;38(3):535-42. PMID:11069677
2. ↑ Hamon MA, Lazazzera BA. The sporulation transcription factor Spo0A is required for biofilm development in Bacillus subtilis. Mol Microbiol. 2001 Dec;42(5):1199-209. PMID:11886552
3. ↑ Castilla-Llorente V, Salas M, Meijer WJ. kinC/D-mediated heterogeneous expression of spo0A during logarithmical growth in Bacillus subtilis is responsible for partial suppression of phi 29 development. Mol Microbiol. 2008 Jun;68(6):1406-17. doi: 10.1111/j.1365-2958.2008.06234.x., Epub 2008 Apr 8. PMID:18410285 doi:10.1111/j.1365-2958.2008.06234.x