4ka4
From Proteopedia
Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)
Function
[ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
About this Structure
4ka4 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
