3rcp

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Template:STRUCTURE 3rcp

Contents

Crystal structure of the FAPP1 pleckstrin homology domain

Template:ABSTRACT PUBMED 21454700

Function

[PKHA3_HUMAN] Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P).[1]

About this Structure

3rcp is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • He J, Scott JL, Heroux A, Roy S, Lenoir M, Overduin M, Stahelin RV, Kutateladze TG. Molecular basis of phosphatidylinositol 4-phosphate and ARF1 recognition by the FAPP1 PH domain. J Biol Chem. 2011 Mar 22. PMID:21454700 doi:10.1074/jbc.M111.233015
  1. ↑ Godi A, Di Campli A, Konstantakopoulos A, Di Tullio G, Alessi DR, Kular GS, Daniele T, Marra P, Lucocq JM, De Matteis MA. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol. 2004 May;6(5):393-404. Epub 2004 Apr 25. PMID:15107860 doi:10.1038/ncb1119

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