3qzv

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Template:STRUCTURE 3qzv

Contents

Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide

Template:ABSTRACT PUBMED 21596426

Function

[BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.

About this Structure

3qzv is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ruthenburg AJ, Li H, Milne TA, Dewell S, McGinty RK, Yuen M, Ueberheide B, Dou Y, Muir TW, Patel DJ, Allis CD. Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell. 2011 May 27;145(5):692-706. Epub 2011 May 19. PMID:21596426 doi:10.1016/j.cell.2011.03.053

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