2woz

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Template:STRUCTURE 2woz

Contents

THE NOVEL BETA-PROPELLER OF THE BTB-KELCH PROTEIN KRP1 PROVIDES THE BINDING SITE FOR LASP-1 THAT IS NECESSARY FOR PSEUDOPODIA EXTENSION

Template:ABSTRACT PUBMED 19726686

Function

[KBTBA_RAT] Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Required for pseudopod elongation in transformed cells.[1]

About this Structure

2woz is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Gray CH, McGarry LC, Spence HJ, Riboldi-Tunnicliffe A, Ozanne BW. Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension. J Biol Chem. 2009 Oct 30;284(44):30498-507. Epub 2009 Sep 2. PMID:19726686 doi:10.1074/jbc.M109.023259
  1. ↑ Spence HJ, Johnston I, Ewart K, Buchanan SJ, Fitzgerald U, Ozanne BW. Krp1, a novel kelch related protein that is involved in pseudopod elongation in transformed cells. Oncogene. 2000 Mar 2;19(10):1266-76. PMID:10713668 doi:10.1038/sj.onc.1203433

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