3rt4

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Template:STRUCTURE 3rt4

Contents

Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein

Template:ABSTRACT PUBMED 21454594

Function

[PGRP1_CAMDR] Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).

About this Structure

3rt4 is a 4 chain structure with sequence from Camelus dromedarius. This structure supersedes the now removed PDB entry 3mu9. Full crystallographic information is available from OCA.

Reference

  • Sharma P, Dube D, Singh A, Mishra B, Singh N, Sinha M, Dey S, Kaur P, Mitra DK, Sharma S, Singh TP. Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein. J Biol Chem. 2011 May 6;286(18):16208-17. Epub 2011 Mar 21. PMID:21454594 doi:10.1074/jbc.M111.228163

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