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3qwl
From Proteopedia
Contents |
Crystal structure of human TBC1 domain family member 7
Function
[TBCD7_HUMAN] Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.[1]
About this Structure
3qwl is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, Manning BD. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell. 2012 Aug 24;47(4):535-46. doi: 10.1016/j.molcel.2012.06.009. Epub 2012 , Jul 12. PMID:22795129 doi:10.1016/j.molcel.2012.06.009
Categories: Homo sapiens | Arrowsmith, C H. | Bountra, C. | Edwards, A M. | Guan, X. | Landry, R. | Park, H. | SGC, Structural Genomics Consortium. | Tempel, W. | Tong, Y. | Weigelt, J. | Wernimont, A K. | Hydrolase activator | Rab gtpase activation | Sgc | Structural genomics consortium | Tbc domain
