Hepatocyte growth factor (HGF) regulates cell growth, motility and morphogenesis. HGF binds to proto-oncogene c-Met receptor and activates a tyrosine kinase signaling cascade. HGF precursor is cleaved by serine protease to α and β (residues 495-728) chains which form a disulfide bond to produce the active heterodimer. HGF NK1 variant is comprised of residues 28-210 containing the N-terminus and the first kringle domain of HGF. HGF NK2 variant is comprised of residues 28-289 containing the N-terminus and the first 2 kringle domains of HGF.
3D structures of hepatocyte growth factor
Updated on 16-May-2013
HGF N terminal
2hgf – hHGF N terminal – human - NMR
3hms, 3hmt – hHGF N terminal
3hmr – mHGF N terminal – mouse
HGF NK1 variant
1bht, 1nk1, 1gp9, 2qj2, 2qj4 – hHGF NK1
1gmn, 1gmo, 3mkp – hHGF NK1 (mutant) + heparin
HGF NK2 variant
3hn4 – hHGF NK2
3sp8 – hHGF NK2 (mutant) + heparin
4iua – mHGF NK2 (mutant)
HGF β chain
1si5 – hHGF β chain (mutant)
1shy – hHGF β chain (mutant) + HGF receptor Sema and ψ domains
