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2ql5
From Proteopedia
Contents |
Crystal Structure of caspase-7 with inhibitor AC-DMQD-CHO
Template:ABSTRACT PUBMED 17697120
Function
[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
About this Structure
2ql5 is a 7 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Agniswamy J, Fang B, Weber IT. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65. Epub 2007 Aug 14. PMID:17697120 doi:http://dx.doi.org/10.1111/j.1742-4658.2007.05994.x
