4iox

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Template:STRUCTURE 4iox

Contents

The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors

Template:ABSTRACT PUBMED 23596306

Function

[TRM3_HHV11] Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. Heterodimerizes with small terminase protein to be docked on capsid portal protein. The latter forms a ring in which genomic DNA in translocated into the capsid. May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation.

About this Structure

4iox is a 4 chain structure with sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

  • Sigamani SS, Zhao H, Kamau YN, Baines JD, Tang L. The structure of the herpes simplex virus DNA-packaging terminase pUL15 nuclease domain suggests an evolutionary lineage among eukaryotic and prokaryotic viruses. J Virol. 2013 Apr 17. PMID:23596306 doi:10.1128/JVI.00311-13

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OCA

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