2xdi

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Template:STRUCTURE 2xdi

Contents 1 Tryptophan repressor with L75F mutation in its apo form (no L- tryptophan bound) 2 Function 3 About this Structure 4 Reference

Tryptophan repressor with L75F mutation in its apo form (no L- tryptophan bound)

Template:ABSTRACT PUBMED 12356295

Function

[TRPR_ECO57] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity).

About this Structure

2xdi is a 2 chain structure with sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

• Tyler R, Pelczer I, Carey J, Copie V. Three-dimensional solution NMR structure of Apo-L75F-TrpR, a temperature-sensitive mutant of the tryptophan repressor protein. Biochemistry. 2002 Oct 8;41(40):11954-62. PMID:12356295