4hr9

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Template:STRUCTURE 4hr9

Contents

Human interleukin 17A

Template:ABSTRACT PUBMED 23695682

Function

[IL17_HUMAN] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.

About this Structure

4hr9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Liu S, Song X, Chrunyk BA, Shanker S, Hoth LR, Marr ES, Griffor MC. Crystal structures of interleukin 17A and its complex with IL-17 receptor A. Nat Commun. 2013;4:1888. doi: 10.1038/ncomms2880. PMID:23695682 doi:10.1038/ncomms2880

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OCA

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