2gvf

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Image:2gvf.gif

2gvf, resolution 2.50Å

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HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021

Overview

Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.

About this Structure

2GVF is a Protein complex structure of sequences from Hepatitis c virus with and as ligands. Full crystallographic information is available from OCA.

Reference

P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease., Arasappan A, Njoroge FG, Chen KX, Venkatraman S, Parekh TN, Gu H, Pichardo J, Butkiewicz N, Prongay A, Madison V, Girijavallabhan V, Bioorg Med Chem Lett. 2006 Aug 1;16(15):3960-5. Epub 2006 May 30. PMID:16730985

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