4iwn

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Template:STRUCTURE 4iwn

Contents 1 Crystal structure of a putative methyltransferase CmoA in complex with a novel SAM derivative 2 Function 3 About this Structure 4 Reference

Crystal structure of a putative methyltransferase CmoA in complex with a novel SAM derivative

Template:ABSTRACT PUBMED 23695253

Function

[CMOA_ECOLI] Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity).

About this Structure

4iwn is a 2 chain structure with sequence from Streptomyces aureorectus. Full crystallographic information is available from OCA.

Reference

• Byrne RT, Whelan F, Aller P, Bird LE, Dowle A, Lobley CM, Reddivari Y, Nettleship JE, Owens RJ, Antson AA, Waterman DG. S-Adenosyl-S-carboxymethyl-L-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA. Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1090-8. doi:, 10.1107/S0907444913004939. Epub 2013 May 15. PMID:23695253 doi:10.1107/S0907444913004939