3q0q
From Proteopedia
Contents |
Crystal structure of the PUMILIO-homology domain from Human PUMILIO2 in complex with p38alpha NREa
Template:ABSTRACT PUBMED 21397187
Function
[PUM2_HUMAN] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
About this Structure
3q0q is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Lu G, Hall TM. Alternate modes of cognate RNA recognition by human PUMILIO proteins. Structure. 2011 Mar 9;19(3):361-7. PMID:21397187 doi:10.1016/j.str.2010.12.019
