4bl6

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Template:STRUCTURE 4bl6

Contents

Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to co-ordinate recruitment of cargos to dynein

Template:ABSTRACT PUBMED 23723415

Function

[BICD_DROME] This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. BicD mutations cause Nanos mislocalization and thus bicaudal development.

About this Structure

4bl6 is a 4 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

  • Liu Y, Salter HK, Holding AN, Johnson CM, Stephens E, Lukavsky PJ, Walshaw J, Bullock SL. Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein. Genes Dev. 2013 Jun 1;27(11):1233-46. doi: 10.1101/gad.212381.112. Epub 2013 May , 30. PMID:23723415 doi:10.1101/gad.212381.112

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