3dpy
From Proteopedia
Contents |
Protein farnesyltransferase complexed with FPP and caged TKCVIM substrate
Template:ABSTRACT PUBMED 18844669
Function
[FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [FNTB_RAT] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
About this Structure
3dpy is a 3 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- DeGraw AJ, Hast MA, Xu J, Mullen D, Beese LS, Barany G, Distefano MD. Caged protein prenyltransferase substrates: tools for understanding protein prenylation. Chem Biol Drug Des. 2008 Sep;72(3):171-81. doi: 10.1111/j.1747-0285.2008.00698.x. PMID:18844669 doi:10.1111/j.1747-0285.2008.00698.x
