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4ixe

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Revision as of 15:04, 19 June 2013 by OCA (Talk | contribs)
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Template:STRUCTURE 4ixe

Contents

pcDHFR-NADPH-270

Template:ABSTRACT PUBMED 23627352

Function

[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

4ixe is a 1 chain structure with sequence from Pneumocystis carinii. Full crystallographic information is available from OCA.

Reference

  • Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V. Design, synthesis and molecular modeling of novel pyrido[2,3-d]pyrimidine analogs as antifolates: Application of Buchwald-Hartwig aminations of heterocycles. J Med Chem. 2013 Apr 29. PMID:23627352 doi:10.1021/jm400086g

Proteopedia Page Contributors and Editors (what is this?)

OCA

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