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2lyh
From Proteopedia
Contents |
Structure of Faap24 residues 141-215
Template:ABSTRACT PUBMED 23661679
Function
[FAP24_HUMAN] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.
About this Structure
2lyh is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Wienk H, Slootweg JC, Speerstra S, Kaptein R, Boelens R, Folkers GE. The Fanconi anemia associated protein FAAP24 uses two substrate specific binding surfaces for DNA recognition. Nucleic Acids Res. 2013 May 9. PMID:23661679 doi:10.1093/nar/gkt354
