2m6n

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Template:STRUCTURE 2m6n

Contents 1 3D solution structure of EMI1 (Early Mitotic Inhibitor 1) 2 Function 3 About this Structure 4 Reference

3D solution structure of EMI1 (Early Mitotic Inhibitor 1)

Template:ABSTRACT PUBMED 23708605

Function

[FBX5_HUMAN] Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.^{[1] [2]}

About this Structure

2m6n is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

• Frye JJ, Brown NG, Petzold G, Watson ER, Grace CR, Nourse A, Jarvis MA, Kriwacki RW, Peters JM, Stark H, Schulman BA. Electron microscopy structure of human APC/C-EMI1 reveals multimodal mechanism of E3 ligase shutdown. Nat Struct Mol Biol. 2013 May 26. doi: 10.1038/nsmb.2593. PMID:23708605 doi:10.1038/nsmb.2593

1. ↑ Hsu JY, Reimann JD, Sorensen CS, Lukas J, Jackson PK. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nat Cell Biol. 2002 May;4(5):358-66. PMID:11988738 doi:10.1038/ncb785
2. ↑ Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK. Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev. 2006 Sep 1;20(17):2410-20. Epub 2006 Aug 18. PMID:16921029 doi:gad.1454006