3ay5

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Template:STRUCTURE 3ay5

Contents

Crystal structure of HHM (human homologue of murine maternal Id-like molecule)

Template:ABSTRACT PUBMED 22453338

Function

[CCDB1_HUMAN] May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.[1]

About this Structure

3ay5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ishii R, Isogaya K, Seto A, Koinuma D, Watanabe Y, Arisaka F, Yaguchi S, Ikushima H, Dohmae N, Miyazono K, Miyazawa K, Ishitani R, Nureki O. Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition. EMBO J. 2012 Mar 27;31(11):2541-52. doi: 10.1038/emboj.2012.77. PMID:22453338 doi:10.1038/emboj.2012.77
  1. ↑ Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M. GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. J Biol Chem. 2000 Jul 7;275(27):20942-8. PMID:10801854 doi:10.1074/jbc.M002598200

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