4j19

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Template:STRUCTURE 4j19

Contents 1 Structure of a novel telomere repeat binding protein bound to DNA 2 Function 3 About this Structure 4 Reference

Structure of a novel telomere repeat binding protein bound to DNA

Template:ABSTRACT PUBMED 23685356

Function

[HMBX1_HUMAN] Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor.^{[1] [2]}

About this Structure

4j19 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Kappei D, Butter F, Benda C, Scheibe M, Draskovic I, Stevense M, Novo CL, Basquin C, Araki M, Araki K, Krastev DB, Kittler R, Jessberger R, Londono-Vallejo JA, Mann M, Buchholz F. HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. EMBO J. 2013 May 17. doi: 10.1038/emboj.2013.105. PMID:23685356 doi:10.1038/emboj.2013.105

1. ↑ Chen S, Saiyin H, Zeng X, Xi J, Liu X, Li X, Yu L. Isolation and functional analysis of human HMBOX1, a homeobox containing protein with transcriptional repressor activity. Cytogenet Genome Res. 2006;114(2):131-6. PMID:16825764 doi:http://dx.doi.org/10.1159/000093328
2. ↑ Zhang M, Chen S, Li Q, Ling Y, Zhang J, Yu L. Characterization of a novel human HMBOX1 splicing variant lacking the homeodomain and with attenuated transcription repressor activity. Mol Biol Rep. 2010 Jul;37(6):2767-72. doi: 10.1007/s11033-009-9815-9. Epub 2009, Sep 15. PMID:19757162 doi:http://dx.doi.org/10.1007/s11033-009-9815-9