4in4
From Proteopedia
Crystal structure of cpd 15 bound to Keap1 Kelch domain
Template:ABSTRACT PUBMED 23647822
About this Structure
4in4 is a 3 chain structure with sequence from Streptomyces aureorectus. Full crystallographic information is available from OCA.
Reference
- Marcotte D, Zeng W, Hus JC, McKenzie A, Hession C, Jin P, Bergeron C, Lugovskoy A, Enyedy I, Cuervo H, Wang D, Atmanene C, Roecklin D, Vecchi M, Vivat V, Kraemer J, Winkler D, Hong V, Chao J, Lukashev M, Silvian L. Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism. Bioorg Med Chem. 2013 Jul 15;21(14):4011-9. doi: 10.1016/j.bmc.2013.04.019. Epub , 2013 Apr 19. PMID:23647822 doi:10.1016/j.bmc.2013.04.019
