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3zcb
From Proteopedia
Contents |
VbhT Fic protein from Bartonella schoenbuchensis in complex with VbhA antitoxin mutant E24G and ATP
Template:ABSTRACT PUBMED 23738009
Function
[VBHT_BARSR] Toxic component of a toxin-antitoxin (TA) module VbhT-VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases, impairing actin assembly in infected cells. [VBHA_BARSR] Antitoxin component of a toxin-antitoxin (TA) module VbhT-VbhA. Acts by inhibiting the adenylyltransferase activity of VbhT; competes with ATP-binding and prevents productive ATP-binding to VbhT.
About this Structure
3zcb is a 2 chain structure with sequence from Bartonella schoenbuchensis. Full crystallographic information is available from OCA.
Reference
- Goepfert A, Stanger FV, Dehio C, Schirmer T. Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with fic fold. PLoS One. 2013 May 30;8(5):e64901. doi: 10.1371/journal.pone.0064901. Print 2013. PMID:23738009 doi:10.1371/journal.pone.0064901
