4inc

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Template:STRUCTURE 4inc

Contents 1 Human Histidine Triad Nucleotide Binding Protein 2 2 Function 3 About this Structure 4 Reference

Human Histidine Triad Nucleotide Binding Protein 2

Template:ABSTRACT PUBMED 23659632

Function

[HINT2_HUMAN] Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.^{[1] [2]}

About this Structure

4inc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Maize KM, Wagner CR, Finzel BC. Structural characterization of human histidine triad nucleotide binding protein 2 (hHint2), a member of the histidine triad (HIT) superfamily. FEBS J. 2013 May 10. doi: 10.1111/febs.12330. PMID:23659632 doi:10.1111/febs.12330

1. ↑ Martin J, Magnino F, Schmidt K, Piguet AC, Lee JS, Semela D, St-Pierre MV, Ziemiecki A, Cassio D, Brenner C, Thorgeirsson SS, Dufour JF. Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. Gastroenterology. 2006 Jun;130(7):2179-88. PMID:16762638 doi:10.1053/j.gastro.2006.03.024
2. ↑ Lenglet S, Antigny F, Vetterli L, Dufour JF, Rossier MF. Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis. Endocrinology. 2008 Nov;149(11):5461-9. doi: 10.1210/en.2008-0400. Epub 2008 Jul , 24. PMID:18653718 doi:10.1210/en.2008-0400