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4b2w

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Template:STRUCTURE 4b2w

Contents

Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor

Template:ABSTRACT PUBMED 23138692

Function

[G3XCK4_PSEAI] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity).[RuleBase:RU003706]

About this Structure

4b2w is a 4 chain structure with sequence from Pseudomonas aeruginosa pao1. Full crystallographic information is available from OCA.

Reference

  • Alphey MS, Pirrie L, Torrie LS, Boulkeroura WA, Gardiner M, Sarkar A, Maringer M, Oehlmann W, Brenk R, Scherman MS, McNeil M, Rejzek M, Field RA, Singh M, Gray D, Westwood NJ, Naismith JH. Allosteric Competitive Inhibitors of the Glucose-1-Phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa. ACS Chem Biol. 2012 Nov 8. PMID:23138692 doi:10.1021/cb300426u

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OCA

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