3zfv

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Template:STRUCTURE 3zfv

Contents

Crystal structure of an archaeal CRISPR-associated Cas6 nuclease

Template:ABSTRACT PUBMED 23527601

Function

[CAS6A_SULSO] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).

About this Structure

3zfv is a 4 chain structure with sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

  • Reeks J, Sokolowski RD, Graham S, Liu H, Naismith JH, White MF. Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing. Biochem J. 2013 Mar 25. PMID:23527601 doi:10.1042/BJ20130269

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