4k1c

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4k1c

Contents 1 VCX1 Calcium/Proton Exchanger 2 Function 3 About this Structure 4 Reference

VCX1 Calcium/Proton Exchanger

Template:ABSTRACT PUBMED 23685453

Function

[VCX1_YEAST] Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.^{[1] [2]}

About this Structure

4k1c is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

• Waight AB, Pedersen BP, Schlessinger A, Bonomi M, Chau BH, Roe-Zurz Z, Risenmay AJ, Sali A, Stroud RM. Structural basis for alternating access of a eukaryotic calcium/proton exchanger. Nature. 2013 May 19. doi: 10.1038/nature12233. PMID:23685453 doi:10.1038/nature12233

1. ↑ Pozos TC, Sekler I, Cyert MS. The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers. Mol Cell Biol. 1996 Jul;16(7):3730-41. PMID:8668190
2. ↑ Cunningham KW, Fink GR. Calcineurin inhibits VCX1-dependent H+/Ca2+ exchange and induces Ca2+ ATPases in Saccharomyces cerevisiae. Mol Cell Biol. 1996 May;16(5):2226-37. PMID:8628289