2lwp

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Template:STRUCTURE 2lwp

Contents

The NMR solution structure of the the ubiquitin homology domain of mouse BAG-1

Template:ABSTRACT PUBMED 23277101

Function

[BAG1_MOUSE] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.[1]

About this Structure

2lwp is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.

Reference

  • Huang HW, Yu C. The NMR solution structure of the ubiquitin homology domain of Bcl-2-associated athanogene 1 (BAG-1-UBH) from Mus musculus. Biochem Biophys Res Commun. 2013 Feb 1;431(1):86-91. doi:, 10.1016/j.bbrc.2012.12.082. Epub 2012 Dec 28. PMID:23277101 doi:10.1016/j.bbrc.2012.12.082
  1. ↑ Takayama S, Xie Z, Reed JC. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem. 1999 Jan 8;274(2):781-6. PMID:9873016

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