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2lw9
From Proteopedia
Contents |
NMR solution structure of Myo10 anti-CC
Template:ABSTRACT PUBMED 23012428
Function
[MYO10_HUMAN] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).[1]
About this Structure
2lw9 is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Lu Q, Ye F, Wei Z, Wen Z, Zhang M. Antiparallel coiled-coil-mediated dimerization of myosin X. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17388-93. doi:, 10.1073/pnas.1208642109. Epub 2012 Sep 10. PMID:23012428 doi:10.1073/pnas.1208642109
- ↑ Bohil AB, Robertson BW, Cheney RE. Myosin-X is a molecular motor that functions in filopodia formation. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12411-6. Epub 2006 Aug 7. PMID:16894163 doi:10.1073/pnas.0602443103
