4e92

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4e92

Contents 1 Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BM4 2 Function 3 About this Structure 4 Reference

Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BM4

Template:ABSTRACT PUBMED 22496222

Function

[Q79791_9HIV1] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS000071_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).[SAAS:SAAS000071_004_011858]

About this Structure

4e92 is a 2 chain structure with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

• Lemke CT, Titolo S, von Schwedler U, Goudreau N, Mercier JF, Wardrop E, Faucher AM, Coulombe R, Banik SS, Fader L, Gagnon A, Kawai SH, Rancourt J, Tremblay M, Yoakim C, Simoneau B, Archambault J, Sundquist WI, Mason SW. Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein. J Virol. 2012 Apr 11. PMID:22496222 doi:10.1128/JVI.00493-12