4jvy

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Template:STRUCTURE 4jvy

Contents 1 Structure of the STAR (signal transduction and activation of RNA) domain of GLD-1 bound to RNA 2 Function 3 About this Structure 4 Reference

Structure of the STAR (signal transduction and activation of RNA) domain of GLD-1 bound to RNA

Template:ABSTRACT PUBMED 23630077

Function

[GLD1_CAEEL] Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline. Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation.

About this Structure

4jvy is a 4 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

• Teplova M, Hafner M, Teplov D, Essig K, Tuschl T, Patel DJ. Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites. Genes Dev. 2013 Apr 15;27(8):928-40. doi: 10.1101/gad.216531.113. PMID:23630077 doi:10.1101/gad.216531.113