2lpn

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Template:STRUCTURE 2lpn

Contents

Solution Structure of N-Terminal domain of human Conserved Dopamine Neurotrophic Factor (CDNF)

Template:ABSTRACT PUBMED 22528768

Function

[CDNF_HUMAN] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).

About this Structure

2lpn is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Latge C, Cabral KM, Almeida MS, Foguel D. (1)H-, (13)C- and (15)N-NMR assignment of the N-terminal domain of human cerebral dopamine neurotrophic factor (CDNF). Biomol NMR Assign. 2012 Apr 18. PMID:22528768 doi:10.1007/s12104-012-9388-8

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